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, atypical antipsychotics, such as clozapine, phenothiazines, most tcas, aspirin, nsaids , or other drugs that may increase risk of bleeding, as well as in patients with a history of bleeding disorders see section 4.

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check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers fever reducers including aspirin, nsaids such as celecoxib, ketorolac, or naproxen .

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the australian market was taken over by aspro , after the makers of nicholas-aspirin lost a short-lived exclusive right to the aspirin name there.

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lithium; insulin or diabetes medicine taken by mouth; an ace inhibitor such as benazepril lotensin , captopril capoten , enalapril vasotec , lisinopril prinivil, zestril , ramipril altace , and others; or indomethacin or other nsaids non-steroidal anti-inflammatory drugs such as aspirin, ibuprofen motrin, advil , diclofenac voltaren , naproxen aleve, naprosyn , piroxicam feldene , nabumetone relafen , etodolac lodine , and others.

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nsaids no benefit in prospective trials netherlands study n 6989 over age 55, for 8 years continuous nsaid use decreased alzheimer s risk relative risk reduction 80 for 2 years of use aspirin did not confer same benefit as nsaid use veld 2001 n engl j med 345 1515-21 pubmed johns hopkins retrospective study n 209 nsaids n 32 slowed alzheimer s progression based on mmse, boston naming, and benton scales rich 1995 neurology 45 51-5 pubmed recent evidence does not support routine use cummings 2004 n engl j med 351 56-67 pubmed selegiline eldepryl 10 mg po qd meta-analysis with not enough evidence to support birks 2003 cochrane database syst rev, cd002854 pubmed hormone replacement therapy testosterone replacement risk of adverse effects and no significanr benefit demonstrated to date lu 2006 arch neurol 63 2 177-85 pubmed estrogen replacement initial studies showed possible benefit recent studies have shown no benefit or worsening references buckwalter 2004 j am geriatr soc 52 182-6 pubmed espeland 2004 jama 291 2959-68 pubmed statins no significant effect on cognition or functional status in moderate alzheimer disease sano 2011 neurology 77 6 556-63 pubmed feldman 2010 neurology 74 12 956-64 pubmed ginkgo biloba 40 mg po tid no significant longterm benefit despite initial studies suggesting possible mild improvement case reports of coma, bleeding, and seizures high drop out rate in studies references le bars 1997 jama 278 1327-32 pubmed oken 1998 arch neurol 55 1409-15 pubmed omega-3 fatty acids no significant effect on cognition or functional status in moderate alzheimer disease quinn 2010 jama 304 17 1903-11 pmid 21045096 pubmed light alcohol consumption 1-6 drinks per week appears to have protective effect against dementia however also has negative cognitive effects mukamal 2003 jama 289 1405-13 pubmed coconut oil axona in theory, brain has altered glucose metabolism, and triglycerides offer alternative nutritional source no significant evidence to support this use risk of increased fat and calorie intake – 12 grams of fat per tablespoon radenahmad 2011 br j nutr 105 5 738-46 pubmed bacopa monnieri brahmi no significant evidence to support use herbal prevagen apoaquorin calcium binding protein derived from jellyfish extract postulated to be neuroprotective no evidence of benefit 2015 presc lett 22 11 65.


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