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To our knowledge, the only publications presenting an analysis of ca 2 i transient during microtubule alteration in adult cardiac myocytes are our recent report, in which an increase in ca 2 i transient after longer colchicine treatment was demonstrated, 18 and one by howarth et al, 19 who showed a decrease in ca 2 i transient after microtubule stabilization with taxol, suggesting that microtubules may be important regulators of ca 2 handling in the heart.

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