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– with sucralfate decreases absorption of amitriptyline; with fluvoxamine – increases the concentration of amitriptyline in blood plasma and the risk of toxic effects; with fluoxetine – increased concentration of amitriptyline in plasma and develop toxic reactions due to inhibition of isoenzyme cyp2d6 under the influence of fluoxetine; with quinidine – may slow metabolism of amitriptyline; with cimetidine – may slow metabolism of amitriptyline, increasing its concentration in blood plasma and the development of toxic effects.

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