Diarrhea, bloody diarrhea, and colitis including pseudomembranous colitis have been reported with the use of orally and parenterally administered clindamycin, as well as with topical dermal and vaginal formulations of clindamycin.
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in this report, evidence is presented that the s -oxidation of clindamycin is primarily mediated by cyp3a.
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biologically inactive clindamycin phosphate disappears rapidly from the serum; the average elimination half-life is 6 minutes; however, the serum elimination half-life of active clindamycin is about 3 hours in adults and 2.
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clindamycin is available under the brand name cleocin, both as a 7-day vaginal cream and as a 3-night vaginal suppository cleocin vaginal ovules which has been approved as an equivalent treatment to the 7-day cream.
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