Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of henle, where it inhibits the na k 2ci – -carrier system.
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the total clearance of unat torsemide sodium is approximately 50 of that seen in healthy volunteers, and the plasma half-life and auc are correspondingly increased.
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in patients with essential hypertension, torsemide has been administered together with beta-blockers, ace inhibitors, and calcium-channel blockers.
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