Some authors have recommended that combinations of cheaper or more cost-effective drugs such as co-trimoxazole with rifampicin or clindamycin be tried before linezolid in the treatment of sstis when susceptibility of the causative organism allows it.
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Resolution was achieved in 17 19 patients and in 9 19, co-trimoxazole was the only form of therapy given.
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Only one small rct reported equivalent efficacy for cotrimoxazole and oral chloramphenicol in children with pneumonia, albeit with limited generalizability.
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In one controlled study in adults with acute shigellosis, a single 800-mg oral dose of norfloxacin was as effective as 5 days of co-trimoxazole therapy.
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