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methotrexate is active orally and parenterally.

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methotrexate has also been used to induce miscarriage in ectopic pregnancies.

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in an editorial about a cochrane review published in july 2013, which considered evidence supporting the use of folic acid to reduce side effects associated with methotrexate, it was pointed out that folic acid use is quite variable some doctors prescribe folic acid to be used regularly by patients taking methotrexate, while other doctors prescribe it only to patients with side effects from methotrexate.

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