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Concurrent treatment with a cyp2d6 inhibitor such as bupropion, fluoxetine, or paroxetine has been shown to increase plasma atomoxetine by 100 or more, as well as increase n -desmethylatomoxetine levels and decrease plasma 4-hydroxyatomoxetine levels by a similar degree.

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the efficacy of paroxetine in the treatment of major depressive disorder, panic disorder, social anxiety disorder, and premenstrual dysphoric disorder pmdd is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin 5-hydroxy-tryptamine, 5-ht .

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no new adverse events were observed in the paroxetine 60 mg dose group compared to any of the other treatment groups.

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